Introduction

The process of drug discovery and development is undergoing a series of revolutionary changes. This is due to three factors:-

♦ The view that conventional, mainly cytotoxic approaches have been successful in the past, but have reached a plateau of effectiveness and therapeutic index with respect to activity in human solid tumours.

♦ The opportunities for novel molecular targets opened up by our new understanding of the molecular biology of cancer.

♦ The range of new technologies that are available today to increase the quality of candidate drugs and to accelerate their discovery and development.

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