Targeted radiotherapy means the selective irradiation of tumour cells by radionuclides that are conjugated to tumour-seeking molecules

(targeting agents). Ideally, the targeting agent should be perfectly efficient in finding every tumour cell in the body and should be absolutely discriminatory in finding only tumour cells. Real agents fall well short of this ideal. In practice, a targeting agent has therapeutic potential if it can be stably conjugated to an appropriate radionuclide and allows significantly higher radiation doses to be delivered to tumour masses than to critical tissues. This is a 'therapeutic ratio' criterion similar to that which applies to most forms of cancer treatment. However, targeted radiotherapy also possesses unique features.

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