Gestational trophoblastic disease (GTD) includes a spectrum of disorders ranging from the pre-malignant complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM), to the malignant invasive mole, gestational choriocarcinoma, and the highly malignant placental-site trophoblastic tumour (PSTT). Both CHM and PHM can develop into invasive moles. However, it is thought that only CHM may progress to the highly malignant choriocarcinoma and the rare PSTT.

Difficulty in diagnosis occurs most frequently with choriocarcino-mas and PSTT, which can arise after any type of pregnancy and may not present until many years later with widespread metastases. GTD remains an important group of disorders for the clinician to recognize, because they are nearly always curable if appropriately managed and, in most cases, fertility can be preserved.

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