Indications for carboplatin

♦ Ovarian cancer

—equal efficacy for carboplatin and CAP (cyclophosphamide, doxorubicin, and cisplatin) —less toxicity for carboplatin compared to CAP —addition of paclitaxel lessens risk of thrombocytopenia

♦ Germ cell tumours

—testicular teratoma: lower relapse rate for cisplatin compared to carboplatin:

—paediatric germ cell tumours: equal efficacy for cisplatin and carboplatin —seminoma: carboplatin, highly efficacious

♦ Paediatric cancers

—cisplatin has role in many cancers —carboplatin less toxic

♦ Small-cell lung cancer —carboplatin, high response rate

♦ Non-small-cell lung cancer, bladder cancer, cervical cancer —carboplatin, slightly better response than cisplatin

—carboplatin combined with paclitaxel, high response rate in non-small-cell lung cancer

♦ Head and neck cancer

—carboplatin used as alternative to cisplatin

♦ Breast cancer

—not used as first-line treatment —used in high-dose regimes

♦ Colon cancer —little activity

♦ Prostate cancer —little data

♦ Brain tumours

—response in medulloblastoma

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