Glutathione is the predominant cellular thiol and participates in a complex biochemical pathway which interacts with the alkylating function of some agents (including cisplatin). Glutathione overexpression in cell lines results in relative resistance to alkylating agent attack. In addition, glutathione is able to detoxify free radicals which may be an important pathway of action for some cytotoxics, including doxorubicin. Clinical trials of glutathione depletion have been performed with somewhat equivocal results.
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