Failure to engage apoptosis

The common final pathway of cell death for many cytotoxics is apop-tosis. This is an active process within cells, somewhat akin to 'cell suicide'. The engagement of the apoptosis program is a complex interacting pathway. At the centre of this is p53, the so-called 'guardian of the genome'. In cells which are unable to engage apoptosis, the damage done by cytotoxics can be 'ignored' and cell division continues. This results in clinical drug resistance. Gene-therapy approaches to correct this apoptosis failure are being actively investigated.

0 0

Post a comment