Dosage of cisplatin

Cisplatin is used in a variety of dosage schedules. The standard dose limit for high-dose therapy is 100 mg/m2 as a single daily dose; higher doses have been explored in clinical trials, particularly in conjunction with neuroprotective agents. Alternate schedules such as five daily injections of 20 mg/m2 are favoured in the treatment of teratoma.

The initial clearance of cisplatin is rapid, followed by a much slower decline due to binding to plasma proteins. Clearance is prolonged in patients with renal insufficiency. Unlike carboplatin, there is no clear evidence of a pharmacodynamic/pharmacokinetic relationship with cisplatin; therefore dosage is usually based on empirical body-surface calculations.

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