Dermatological paraneoplastic syndromes


Common; characteristic of HD, leukaemias, CNS tumours, NHL.


Acanthosis nigricans Itchy brown hyperkeratotic plaques, mainly in flexures; may precede cancers by many years; associated with GIT tumours e.g. gastric adenocarcinoma.

Vitiligo Patchy depigmentation, especially face, neck, and hands; associated with malignant melanoma; possibility due to anti-melanoma immune response.


Necrolytic migratory erythema Islet cell tumour. Exfoliative dermatitis—cutaneous T-cell lymphoma.


Pemphigus Characteristic bullous lesions on skin and mucous membranes; associated with lymphoma, Kaposi's sarcoma, thymic tumours.

Dermatitis herpetiformis Chronic, intensely itchy vesicles over elbows, knees, and lower back; precede tumour by many years; associated with lymphomas e.g. NHL of the small intestine.

How To Prevent Skin Cancer

How To Prevent Skin Cancer

Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.

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