Contents

Preface v

List of contributors ix Abbreviations xvii

Part 1

Background

1 Multidisciplinary approach to cancer 2

2 Epidemiology of cancer 3

3 Biology of cancer 11

4 Pathology of cancer 37

5 Aetiology of cancer 49

6 Staging of cancer 63

Part 2

Principles of treatment

7 Surgical oncology 83

8 Principles of radiation oncology 93

9 Principles of chemotherapy 135

10 Hormone therapy 181

11 Immunotherapy of cancer 189

Part 3

Principles of prevention and care

12 Cancer prevention and screening 207

13 Clinical trials 221

14 Principles of palliative care 227

15 Psychosocial aspects of cancer 249

Part 4

Specific types of cancer

16 Thoracic cancer 261

17 Breast cancer 295

18 Colorectal cancer 323

19 Anal cancer 339

20 Upper gastrointestinal cancer 349

21 Endocrine cancers 375

22 Genitourinary cancers 389

23 Gynaecological cancer 417

24 Head and neck cancer 443

25 Tumours of the central nervous system 469

26 Skin cancer 481

27 Hematological malignancies 489

28 Bone and soft tissue malignancies 515

29 Cancer of unknown primary site 531

30 Paraneoplastic syndromes 543

31 AIDS-related malignances 559

Part 5

Emergencies in oncology

32 Spinal cord compression 573

33 Bone marrow suppression 583

34 Superior vena cava obstruction 591

35 Raised intracranial pressure 599

36 Stridor 605

37 Acute blood loss 611

38 Obstruction 619

39 Biochemical crises 625

Part 6

The way forward

40 Novel therapeutic strategies 637

41 Gene therapy for cancer 655

Part 7

Appendices

1 NCIC common toxicity criteria (CTC) grading system 667

2 Nomogram for determination of body surface area 681

Index 683

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