Clinical indications for cisplatin

Cisplatin was a major step forward in the treatment of testicular cancer. In patients with metastatic disease, cisplatin-based combination therapy results in a complete clinical response in over 80% of patients, with the majority of these achieving long-term cure. Cisplatin is also a major component of treatment of:

♦ Ovarian cancer

♦ Bladder cancer

♦ Penile cancer

♦ Cervical carcinoma

♦ Other squamous carcinomas, particularly those in the head and neck and non-small-cell bronchogenic carcinoma

Combinations of cisplatin with other cytotoxic agents are common and are used in a variety of human solid cancers and paediatric tumours.

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