Chromosomal abnormalities

♦ structural

♦ numerical Examples include:

♦ Chronic myeloid leukaemia

—small chromosome 22 (Philadelphia chromosome)

♦ Acute myeloid leukaemia

—many cytogenic abnormalities (80% of patients)

♦ Therapy-related AML

♦ Myelodysplastic syndromes

—50% have chromosomal abnormalities

♦ Myeloproliferative disorders

♦ Acute lymphocytic leukaemia

—80% have chromosomal abnormalities

♦ Chronic lymphoproliferative disorders

—many structural and numerical chromosomal abnormalities

♦ Neuroblastoma

—deletion of 1p and amplification of N-myc

♦ Wilms' tumour (nephroblastoma)

—many chromosomal abnormalities reported

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