Causes of bone marrow failure

♦ Depletion of anatomical and physiological elements e.g. myelofibrosis, myelodysplasia

♦ Intrinsic stem cell/precursor cell failure e.g. aplastic anaemia, paroxysmal nocturnal haemoglobinuria

♦ Iatrogenic e.g. chemotherapy, irradiation

♦ Bone marrow infiltration e.g. malignancy

♦ Peripheral consumption e.g. hypersplenism

♦ Autoimmune diseases e.g. systemic lupus erythematosis

♦ Vitamin deficiency e.g. megaloblastic anaemia

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