Activity of carboplatin
Carboplatin can be regarded as a less toxic substitute for cisplatin and is used for similar indications. Patients resistant to cisplatin will also be resistant to carboplatin and vice versa. However, the increased thrombocytopenia seen with carboplatin may be a disadvantage in some combinations, while reduced non-haematological toxicities may be an advantage in others. Further, a low level of non-haematological toxicity makes carboplatin suitable for inclusion in high-dose regimens with bone marrow or stem cell rescue.