Figure 3.2.2. A. Structures of BCL molecules. The BCL superfamily comprises three families. The BCL-2 group promotes cell survival, whereas the BAX and BH3-only groups facilitate apoptosis. BH1 and BH4 are conserved sequence motifs. The BAX family resembles the BCL-2 family but lacks functional BH4 domains. The BH3-only family is not homologous to the others, except for its signature motif. a1 though a7denote helices in BCL-Xl, in which a core of the two hydrophobic helices a5 and a6 is flanked by five amphipathic helices. A flexible loop connects a1 with a2. The arrows indicate serine and threonine residues that can be phosphorylated.
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