Natural Breast Enlargement

Boost your Bust Natural Breast Enlargement

This eBook from Jenny Bolton is a must-have for anyone woman who has ever felt like less of a woman because of the size her breasts. If you have ever wished that you have biggest breasts and feel self-conscious about your lack of size, this eBook teaches you the best ways to increase your size. Jenny was able to go from an A cup to a C cup, and she can teach you to do the same thing in this ebook guide. You can be the envy of every woman around you and the center of attention for every man that is close by. It can take less than 5 weeks to grow your breasts to the size that you want them! You will be able to wear sexy clothes that cling to your curves, wear dresses that show off what you've got going on, and get more attention from men! More here...

Boost your Bust Natural Breast Enlargement Summary


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Author: Jenny Bolton
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Bigger Breast Formula

Bigger Breast Formula is an eBook that shows you different herbs and exercises you can use to grow your breast from small breast to voluptuous breast within 3 to 4 months. The methods taught by this book are 100% natural and completely dependent on herbs and exercises. The book will also teach you foods to eat to aid fast breast growth and certain foods you must avoid. It is perfect for women of all ages who are embarrassed by the small breast and want to naturally increase it without risking breast cancer through plastic surgery or implant. The product was created by Sahar Perske from her grandmother's recipe. The author also claimed she used the same formula you will get to increase her own breast from 32A to 34C. All her friends got a similar result when they tried the product. You will get 24/7 live support and well as money back guarantee when you get the product. More here...

Bigger Breast Formula Summary

Contents: Ebook
Author: Sahar Perske
Official Website:
Price: $33.95

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OF NFjBdriven Gene Induction By Phytoestrogens

In this respect, we and others are investigating in more detail how phytoestrogens can specifically modulate NF-kB driven gene expression (i.e., IL6, IL8, iNOS, COX2, ). Multiple lines of evidence indicate that IKK, PI3K, MAPK, and hormones are key elements of the intracellular-signaling cascades regulating NF-kB activity, and various levels of crosstalk have already been described (2,8,114,183,184). For example, breast cancers often progress from a hormone-dependent, nonmetastatic, anti-estrogen-sensitive phenotype to a hormone-independent, antiestrogen- and chemotherapy-resistant phenotype with highly invasive and metastatic growth properties (185-195). This progression is usually accompanied by transition from inducible to constitutive receptor tyrosine kinase (RTK) MAPK signaling which affects ER function (becomes hormone ligand-independent), NF-kB regulation (high turnover of its inhibitor IkB results in constitutive NF-kB activity), or outgrowth of ER-negative In the past few...

Phytoestrogens and Reproduction

Whether phytoestrogens found in many plant foods have played any role in reproductive success at a level that may have evolutionary implications is unclear. However, these isoflavones compete with endogenous estrogens such as estradiol for occupancy of the estrogen receptor (ER), which is common to many reproductive tissues. The bound ligand is responsible for activation of the genomic estrogen response element within the nucleus and, hence, protein expression. An excessive stimulation of ERs in reproductive tissue is associated with poor fecundity. This area is covered in more depth later.

Cancer And Phytoestrogens

Phytoestrogens have been considered to have a preventive effect against various cancers. The consumption of phytoestrogen-rich foods such as soy, a source of isoflavones, and whole grain products, which contain lignans, is thought to play a role in the prevention of breast, prostate, and colon cancer. Other cancers also may be influenced by the presence of dietary phytoestrogens, but the studies in humans are comparatively few. Soy isoflavones may also reduce breast cancer risk by affecting endogenous sex hormone concentrations and prolonging the menstrual cycle. There is evidence from early studies in vitro and in vivo that suggests that phytoestrogens stimulate the production of sex hormone-binding globulin (SHBG) in liver cells.20 An increase in SHBG would lead to lower free-sex hormone concentrations. Longer menstrual cycles, which would lower breast cancer risk, have been seen in young women placed on soy experimentally. 21 The consumption of soy foods has also been associated...


It has been well established that cancer rates differ strikingly in various populations. Hormone-related cancers of breast, ovary, endometrium, and prostate have been reported to vary by as much as 5- to 20-fold between populations, and migrant studies indicate that the difference is largely attributed to environmental factors rather than genetics (31-33). The highest incidences of these cancers are typically observed in populations with Western lifestyles that include relatively high fat, meat-based, and low-fiber diets, whereas the lowest rates are typically observed in Asian populations with Eastern lifestyles that include plant-based diets with a high content of phytoestrogens (34-39). Migrants from Asian to Western countries, who maintain their traditional diet, do not show increased risk for these diseases, whereas an increased risk accompanies a change towards a Westernized diet (31,40). Much of the evidence is based on the differences in consumption of soy products as the...

Breast Cancer Cell Motility Molecular Targets For Possible Antimetastatic Agents

Other agents are currently being used in treatment and prevention of cancer, and, through a better knowledge of their action mechanisms, appear to reduce breast cancer motility and metastasis. Examples of such molecules are the bisphosphonate zoledronic acid (151-153), the soy phytoestrogens genistein and daidzein (via NFkB) (154), green tea polyphenols (via uPA secretion) (155), modified citrus pectin (via galectin-3) (156) and the phytosterol P-sitosterol (via cell-matrix adhesion) (157). Still other molecules, like y-linoleic acid, are promising, because they inhibit cancer cell motility and angiogenesis (158).

Epidemiologic Investigation

Forensic epidemiology is a new discipline. However, epidemiologic evidence has proven to be powerful in litigation involving such diverse hazards as swine flu vaccine, Agent Orange, silicone breast implants, and tampons.36 Several studies describe the use of epidemiological evidence in legal proceedings.37-43

Interactions Between CAM and Conventional Oncologic Therapy

Hormonal interactions Many botanicals, including soy, chasteberry, dong quai, ginseng, and red clover, contain phytoestrogens, or plant-based estrogen-like substances. These compounds may interfere with antiestrogen therapies such as tamoxifen or raloxifene, or promote the growth of estrogen-sensitive tumors.83,84 Indeed, genistein, the predominant isoflavone in soy products, reduced the inhibitory effect of tamoxifen in a mouse model of breast cancer.85 Similarly, black cohosh increased the proliferation of MCF-7 breast cancer cells in vitro.86,87 Although some authors claim the opposite effect, that is, that botan icals containing phytoestrogens can inhibit breast tumor cell growth or potentiate antiestrogen therapy,88 the possibility of harmful interactions will remain a concern until studies are conducted.

Cyclooxygenase Activity And Expression

The structural similarity between resveratrol and the synthetic estrogen diethyl-stilbestrol provided the first clue that resveratrol may function as a phytoestrogen. Estrogen-receptor (ER) agonists bind to the receptor and induce ER binding to estrogen response elements (EREs) in the promoters of target genes with the effect of promoter activation. Phytoestrogens are dietary nonsteroidal agents with ER agonist or mixed ER agonist antagonist activity. In the first definitive analysis of resveratrol effects on the transcriptional activity of the ER, Jameson's group37 established that resveratrol competitively bound ER expressed by MCF7 cells, and activated an ERE-containing promoter-reporter gene construct in MCF7 cells but not a derived construct with the ERE deleted. Furthermore, resveratrol-induced activation of the ERE-containing promoter was abrogated by the pure antiestrogen ICI 182780, indicating that transcriptional activation entailed res-veratrol binding to the ER and thus...

Dietary Components Implicated in Carcinogenesis

Procarcinogenic factors in the diet include sedentary lifestyle, excess energy intake and specific dietary substances. Energy intake is positively correlated with cancer risk and mortality 9 . Interestingly, elevated BMI, an indicator of obesity and therefore a surrogate for excess energy intake, does not seem to influence cancer risk, whereas actual energy expenditure and energy intake significantly influence risk 10 . Epidemiologic studies indicate that cancers of the gastrointestinal tract are amongst the most susceptible to modification by dietary factors 11 . The mechanisms of dietary carcinogenesis fall into several categories direct DNA damage (e.g., nitrites), cytochrome activation or inhibition (e.g., alcohol), carcinogen activation (e.g., pickled salted foods), direct cytotoxicity (e.g., mycotoxins), oxidative damage (e.g., saturated fats), alterations in physiology (e.g., rice, dietary fiber) and hormonal effects (e.g., phytoestrogens).

Usamah S Kayyali and 2Paul M Hassoun

Hormones such as prolactin and glucocorticoids are also important in regulating XOR expression. Both hormones upregulate XOR in mammary epithelial cells. XOR upregu-lation by prolactin and cortisone (both important for lactation) is probably relevant to the mechanisms of secretion and activation in milk, a very rich source of this enzyme. However, upregulation of XOR by glucocorticoids has also been observed in human kidney epithelial cells 8 and rat pulmonary microvascular endothelial cells (Kayyali and Hassoun, unpublished data). Since corticosteroids are important in inflammation, the latter action might be related to the putative role of XOR in the acute phase response and inflammation as discussed later. Estrogens, on the other hand, inhibit the upregulation of XOR by hypoxia in pulmonary microvascular endothelial cells. However, the finding that the nonreceptor-binding a-estradiol also inhibits XOR upregulation suggests a novel antioxidant property for estrogen-related...

Estrogenic and Antiestrogenic Effects

A number of natural compounds can produce estro-genic and antiestrogenic effects. These compounds, which include isoflavonoids, flavones, and flavonols, as well as stilbenes like resveratrol and mammalian lignans like those produced after flaxseed ingestion, are referred to as phytoestrogens. (Resveratrol and flaxseed are discussed in Chapter 20.) Using the same reasoning, when estrogen levels are high (as in premenopausal women), we would expect genistein or other phytoestrogens to produce antiestro-genic effects. The effects of genistein on premenopausal women, however, are still uncertain. Mild estrogenic effects from genistein have been reported in some human studies, and two studies have noted that soy intake (at 38 to 60 grams per day) had a stimulatory effect on the breast tissue of healthy premenopausal women.39-42 In another study, a high (60 gram) soy diet for two weeks produced estrogenic effects in the healthy breast tissue of premenopausal women, but these effects were...

Effects of Isoflavones in Estrogen Dependent Tumors in Animals

If genistein and other phytoestrogens can, under some conditions, stimulate proliferation of estrogen-dependent cancer cells in vitro, we want to know whether this effect occurs in vivo. Unfortunately, very few in-vivo studies have been conducted with estrogen-dependent cancers. One, discussed in more detail later, reported that luteolin reduced growth of human breast cancer cells in mice.25 In a study on soy, administration of a very large dose (20 percent of diet) to mice with transplanted human breast cancer cells did not affect growth of the primary tumor but did reduce proliferation of metastatic tumors in the lungs.57 One study on genistein also reported anticancer effects, but these were surprising considering the low dose used (roughly 15 milligrams per day, as scaled to humans), and additional study is needed to verify these findings

Type II Estrogen Receptors

One reason why phytoestrogens other than genistein may be less problematic is that they appear to inhibit cancer through additional estrogen-receptor-related means. Thus far we have discussed the effects of genistein and other phytoestrogens on what is called the classic estrogen receptor, or type I receptor. A second

Mandated Postmarket Studies

Although there may be difficulties in study conduct, an example of a Section 522 study reveals the authority's public health importance and its risk assessment role. In 1991, FDA scientists demonstrated that it was possible for polyurethane to break down under laboratory conditions to form 2,4-toluenediamine (TDA). TDA had been shown to be an animal carcinogen. Prior to this it was thought that breakdown could only occur at very high temperatures and pH extremes. The firm that manufactured polyurethane foam-coated breast implants ceased sales in 1991 and agreed to a clinical study under Section 522. The study involved comparing TDA levels in urine and serum samples from women with and without the implants. Although minute amounts of TDA were found in the majority of women with the implants, the increase in cancer risk was determined to be vanishingly small (1 in 1 million) (Hester et al., 1997 DoLuu et al., 1998). The FDA issued a public health correspondence (FDA Talk Paper) on the...

Components and Nutraceutical Characteristics of Soybean

Composition of the intestinal microflora and thereby alters the transformation of primary bile acid to secondary bile acids. Secondary bile acids are presumed to be promoters of cell proliferation, which supports mutations and increases the frequency of replications of abnormal cells. Antioxidants may reduce the risk of cancer by preventing the production of or by scavenging reactive free radicals, or by enhancing the activity of detoxifying enzymes. Antioxidants include nutrients such as vitamins C, E, and P-carotene, and trace elements such as Se, Cu, Zn, and Mn, which are components of antioxidative enzymes, and nonnutrients such as phenolic compounds (phenolic acids, lignans). Cereals are rich in phenolic acids, approaching 500 mg kg, which are mainly present in the outer layers of the grain. In wheat bran the major antioxidants are ferulic, vanillic, and p-coumaric acids. In addition, combinations of phenolic acids are claimed to have anticarcinogenic activities. Lignans and...

Planar Myocardial Perfusion Imaging Fig 1496 to Fig 1498

Planar adenosine stress (S)-redistribution (RD) thallium-201 images of a patient with large breasts. There appears to be a reversible anterior wall defect on the left anterior oblique (LAO) and left lateral (LAT) images and anterior images (ANT). However, there are also a large breast shadow visible, in particular, on the LAO and ANT images. This could be a cause for anterior defects. Because the LAT images are acquired in right-side decubitus position, breast attenuation is usually not a problem on these views. In order to interpret these images, the overlap of breast over the heart should be defined. Fig. 14-96. Planar adenosine stress (S)-redistribution (RD) thallium-201 images of a patient with large breasts. There appears to be a reversible anterior wall defect on the left anterior oblique (LAO) and left lateral (LAT) images and anterior images (ANT). However, there are also a large breast shadow visible, in particular, on the LAO and ANT images. This could be a cause...

Hormone Replacement Therapy

Several genetic conditions lead to a failure of ovarian development. These genetic alterations lead to a failure in the synthesis of normal amounts of estrogen or progesterone, so that female secondary sex characteristics do not appear at puberty. Only with estrogen treatment is there stimulation of the growth of the genitalia, breast enlargement, and development of female body contours and distribution of body hair. Some increases in body height also occur with estrogen therapy, but this is more marked after androgen treatment. Replacement estrogens can be administered using a transdermal patch formulation or micronized estradiol (Estrace, Gynodiol).

Using Serum Igf1 As A Surrogate Endpoint Biomarker Of Developing Primary And Secondary Breast Cancer

Several studies have suggested an association between breast volumes density and risk of breast cancer (77). Measurement of breast densities using computer-assisted analysis of mammograms has shown a consistent association between high breast density and breast cancer risk. IGF-1 stimulates cell proliferation, reduces apoptosis, and is associated with larger breast volumes (78, 79). Hartmann et al. showed that in women who underwent hormonal breast augmentation, only women who lacked the 19-repeat allele demonstrated a substantial increase in breast volume (81) whilst other studies studies noted that larger breasts may be associated with higher risk of breast cancer (82). Jernstrom et al. showed that OC users with absent 19-repeat alleles had larger body-weight

Conclusion Of Prostate Cancer

Epidemiological studies did not show a consistent relationship between risk of breast cancer and lignan exposure based on lignan intake, urinary lignan excretion, or plasma lignan levels. However, a majority of the studies show a negative relationship. On the other hand, experimental studies using either FS or the lignans have shown that both can prevent tumor development and decrease tumor growth, although a clear mechanism of action is yet to be established. Because the lignans are phytoestrogens, they are thought to act through the ER pathway however, other nonhormone-mediated effects have also been observed. Gene array analysis of tumors treated with FS may be useful in identifying pathways that are affected by FS. With encouraging results from animal studies, clinical studies on the effect of FS and lignans on breast cancer should be conducted in the future. In particular, the interesting finding that FS in combination with TAM is more beneficial than TAM alone in reducing tumor...

Growth and Development

Estrogens cause the growth of the uterus, fallopian tubes, and vagina. Stimulation of proliferation of the vaginal epithelium is checked by the cyclical exposure to progesterone during the luteal phase in the mature female. Estrogens also are responsible for the expression of female secondary sex characteristics during puberty. These include breast enlargement, the distribution of body hair, body contours as determined by subcutaneous fat deposition, and skin texture. During development, estrogens stimulate proliferation of the ductal epithelial cells in breast tissue. Progesterone mediates lobuloalveolar development at the ends of these mammary ducts. In women, cyclical changes in the breast cell proliferation occur during the menstrual cycle, with the highest levels of proliferation occurring during the luteal phase, when circulating levels of both estrogen and progesterone are high. This has led to the idea that progesterone, as well as estrogens, exerts mi-totic effects in adult...

About the Editors

Awad is an associate professor of nutrition and biochemistry at the State University of New York at Buffalo. He obtained his Ph.D. degree in nutrition from Rutgers University, New Jersey, and completed postdoctoral training in biochemistry at the University of Iowa. He has supervised more than 75 M.S. and Ph.D. students. He has published 70 papers and has presented more than 70 abstracts at scientific meetings. His research focus is in the area of dietary lipids and disease prevention, including the effects of phytochemicals, such as phy-tosterols and phytoestrogens, on cardiovascular disease and cancer.

Lifestyle Factors

International differences in breast cancer occurrence might be partly explained on the basis of lifestyle factors, such as diet and alcohol consumption. Among the dietary factors, the most of the studies have focused on diet content of fat and fiber. As for micronutrients, phytoestrogens have been largely and still inconclusively investigated. Alcohol consumption has shown a moderate effect on breast cancer risk. The existing evidence about dietary components and alcohol intake in affecting breast cancer risk is discussed in detail further in the following chapters of this manuscript.


Physical description Covered with reddish-black hair. Dark skin. Thick head-hair that hangs down the back like a mane. Low forehead. Eyes with a reddish tinge. Flat nose. High cheekbones. Enormous teeth. Muscular arms and legs. Females have large breasts and buttocks. Fingers long and thick. Splayed feet.

Rat Models

The effects on tumor inhibition may be related to the action of phytoestrogens in breast development. A reduction in the number of highly proliferative terminal end bud (TEB) structures in the developing mammary gland through differentiation to the less proliferative alveolar buds and lobules has been suggested to be protective against mammary cancer. Exposure to 5 to 10 flaxseed during gestation and suckling or throughout life significantly reduced TEB density in the mammary gland, whereas exposure after weaning had no effect. When the experiment was repeated with rats exposed to flaxseed only during gestation or gestation to postnatal day 50, the data indicated that the critical period for enhancing the mammary gland differentiation was during suckling. The flaxseed and SDG diets reduced the tumor incidence by 31.3 and 42 , respectively, total tumor load by 50.8 and 62.5 , respectively, and mean tumor size by 43.9 and 67.7 , respectively. These findings supported the hypothesis that...


Rotating planar projection images of a patient with large breasts. Chest circumference was 44 inches (112 cm) and bra cup size was DD. Note that both the right and left breasts can be seen as shadows that move over the screen. The left breast almost completely eclipses the heart.

Hormone Activity

The role of sex hormones in cancer development is well established and has been cited as a contributing factor in one third of all cancer incidences. Estrogens are known to increase the division of cells in hormone-dependent tissues such as the breast and ovaries.1 It has been suggested that the spatial relationship between the phenolic hydroxyl groups of certain flavonoids is similar to that of estradiol allowing flavonoids to interact with estrogen receptors and to exhibit physiological effects similar to estrogens.47 Because flavonoids share this structural similarity with steroids, retinoids, and thyroid hormones,82 many classes of flavonoids, and particularly isoflavonoids, have been referred to as phytoestrogens. Phy-toestrogens are known to bind estrogen receptors exerting both estrogenic and antiestrogenic effects depending on their concentration, the concentration of endogenous sex hormones present, and the receptor activity of the target tissue involved. The majority of...


Certain foods contain plant estrogens that are helpful in balancing hormone levels in the body. Phytoestrogens are similar in structure to estrogen and can alleviate and prevent menopausal symptoms. Soybeans, for example, contain natural estrogens called isoflavones that help prevent osteoporosis, heart disease, and estrogen-related cancers such as breast cancer. In a study, soybeans and flaxseed were tested and found to increase estrogenic activity in postmenopausal women when they stopped eating the foods, estrogen cell activity also dropped. One cup of soybeans contains 300 mg isoflavones which equals the estrogenic effect in one Premarin (a synthetic hormone) tablet.

Protease Inhibitors

All protease inhibitors can produce nausea, vomiting, diarrhea, and paresthesia. Drug-induced hyper-glycemia and insulin resistance may precipitate the onset of diabetes mellitus or worsen existing cases. Protease inhibitors may also cause hypercholester-olemia and hypertriglyceridemia. Liver enzymes may be increased, and hepatic toxicity may occur at high doses. Fat redistribution is common and can manifest as central fat accumulation, peripheral wasting, buffalo hump at the base of the neck, breast enlargement, and or lipomas.

Applied Epidemiology

Oxygen therapy) and develops device-specific supplements to nation-wide surveys (e.g. US National Home and Hospice Care Survey to assess home use of devices) (Bright, 2000). In addition, the program explores enhanced surveillance (e.g. through a nation-wide surveillance network of emergency departments operated by the US Consumer Products Safety Commission), develops and expands existing device registries (e.g. exploring the use of transmyocardial revascularization using the Society of Thoracic Surgeons National Adult Cardiac Surgery database), helps design and analyze mandated postmarket studies, reviews and assesses observational literature (e.g. studies of cellular phones and their relation to brain cancer), and conducts applied research (e.g. breast implants and rupture rates) (Brown et al., 2000). These limitations not withstanding, epidemiology continues to play a vital role in addressing agency device concerns. The role of epidemiology is exemplified by the following two cases....


Estrogen action can be altered by compounds that are estrogen-like in structure (i.e., phytoestrogens) that compete with or inhibit estrogen from binding to the ER (ERa or ERP), thus decreasing its proliferative stimulus. The ER is a member of the steroid nuclear receptor superfamily of ligand inducible transcription fac-tors.74 Estrogen binds to the ligand-binding domain of the ER inducing a confor-mational change that enables binding of certain coactivators or corepressors. The Competition with estrogen for binding to the ER, at target tissues, can modulate estrogen activity and inhibit estrogen action or potentially activate the ER in a way similar to estrogen. It has been shown previously that other phytoestro-gens, such as the isoflavones GEN and equol, bind to ERp with a higher affinity than to ERa.77 This finding suggests that the phytoestrogens may elicit their estrogenic or antiestrogenic effects through this ER subtype. Mueller et al.78 recently determined the binding...

Chris Good

Those wanting plastic surgery breast implants, plastic nose jobs, or only heart transplants for non-smokers If limited to those not taking part in hazardous pursuits, we should have to exclude not only all smokers, all alcoholics, all drug addicts and those injured during criminal activities, etc., but also all vehicle drivers and all those doing sporting activities.


In the past decade, nutrition research has undergone an important shift in focus from epidemiology and physiology to molecular biology and genetics. This is a result of a growing realization that the effects of nutrition on health and disease cannot be understood without a profound understanding of how nutrients act at the molecular level micronutrients and macronutrients can be potent dietary signals that influence the metabolic programming of cells and have an important role in the control of homeostasis and or disease (28,240). Phytoestrogens are plant-derived molecules with estrogen-like action. Numerous reports exist on the potential beneficial role of nutritional phytoestrogens in human health (cancer chemoprevention, relief of postmenopausal symptoms, osteoporosis amelioration) (13-15,18-20). Herbal extracts are frequently used in traditional Chinese medicine for the treatment of hormonal disturbances or as health benefiting supplements (19). Often these preparations are...

Experimental Studies

One suggested hypothesis regarding why Asian women have a lower incidence of breast cancer compared to European and American women is that exposure to phytoestrogens at an early age enhances the development of the mammary gland thereby making it less susceptible to carcinogens.31 The rat mammary gland has been utilized for decades as a model of the human breast. Mammary gland groups. The mice that were given a combination of lignans and isoflavones (ENL + END + GEN) had tumors that did not differ in size compared to the BD-fed animals, showing a more beneficial effect on breast tumor growth when these phytoestrogens are consumed in combination as opposed to genistein alone.

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