In this review we analyze the last thirteen patients with Lennox-Gastaut syndrome (LGS) selected from patients of the Epilepsy Surgery Clinic of the General Hospital of Mexico on the basis of having generalized difficult-to-control seizures of the LGS type. They underwent ESCM with the idea to correlate seizure type, stereotaxic targeting, and neurophysiologic responses with the final outcome of the patient. The Lennox-Gastaut syndrome is one of the severest forms of childhood epilepsy. It is characterized by drug-resistant generalized seizures, the tonic and atonic seizures, atypical absences, myoclonic attacks, and episodes of nonconvulsive and tonic status epilepticus being most characteristic. The peak onset is known to be between 1 and 7 years of age. It is usually preceded by other types of seizure disorders, especially infantile spasms. LGS is accompanied by severe mental deterioration as it progresses. From the electroencephalograph (EEG) standpoint, the diagnosis is based on the presence of slow spike-wave complexes (<2.5 cps) and bursts of rapid (10 Hz) rhythms during slow sleep. The overall prognosis is very severe; 90% of the patients are mentally retarded and 80% continue to have seizures through adulthood (Aicardi, 1994). The selected patients had either secondary LGS with stable or nonprogressive diseases (birth trauma, postencephalitic sequelae, cortical dysplasia, and stable tuberous sclerosis) or primary LGS with no demonstrable lesion in the MRI (magnetic resonance image).
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