C

Compression-dominated compression

Unloaded region fmromm static

Fig. 6. Finite element model (FEM) simulations and corresponding isolation of loading components in vitro. Traumatic loading to the brain results in the generation of complex, heterogeneous strain patterns at tissue and cell levels. Heterogeneity in the cellular response to traumatic loading may be due to several factors, including mode of deformation, cell population, and cell orientation. Neural cell tolerances to traumatic loading may therefore be elucidated based on these parameters.

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