Prostaglandins

Unique to the pre-crossclamp approach among procured organs is the pre-treatment of the pulmonic vasculature with prostaglandin El (Prostin VR). Prostaglandins and prostanoids are potent eicosanoid pulmonary microvascular dilator agents; they are administered to counteract the vasoconstrictive effects of high K+ "intracellular"-type solutions (i.e., EC and UW). Additional effects include inhibition of pulmonary intravascular leukocyte sequestration, stabilization of lysosomal membranes, bronchodilation, suppression of vascular endothelial permeability, and inhibition of platelet aggregation. Immunologic effects of this class of compounds include inhibition of T-lymphocyte cytotoxicity and mitogenesis and diminished production of interleukin-2 (IL-2).7 Prostaglandin E is metabolized in the lungs.

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