Experimental Brain Death Ex Vivo Hemodynamics

Fig. 3.9. Ex vivo hemodynamic testing of hearts procured from: (A) alive animals, (B) brain-dead, (C) brain-dead, T3 treated animals, (D) brain-dead and stored, and (E) brain-dead, T3 treated and stored. A vs. B p < 0.01 vs. A p < 0.001. Groups C and E were no different from Group A.

Fig. 3.9. Ex vivo hemodynamic testing of hearts procured from: (A) alive animals, (B) brain-dead, (C) brain-dead, T3 treated animals, (D) brain-dead and stored, and (E) brain-dead, T3 treated and stored. A vs. B p < 0.01 vs. A p < 0.001. Groups C and E were no different from Group A.

Table 3.1. Hemodynamic and metabolic study of hearts procured from live, brain-dead, and brain-dead hormonally treated pigs tested in a modified ex vivo Langendorf model

Groups

CO

LVEDP

ATP

CP

Lactate

Glycogen

(mL/min)

(mm Hg)

(^mol/g)

(pmol/g)

(pmol/g)

(pmol/g)

Nonstored

Alive

2320 (220)

5.30 (1.03)

3.73 (0.25)

6.61 (0.72)

5.0 (0.7)

29.6 (3.14)

BD1850 (329)

4.30 (O.59)

3.29 (0.22)

3.69 (0.85)

12.9 (3.39)

12.7 (2.95)

p < 0.02

ns

ns

0 < 0.02

p < 0.01

p < 0.005

BD and HT

2357 (406)

3.80 (1.68)

3.75 (0.38)

6.80 (1.14)

7.07 (1.56)

30.5 (4.21)

ns

ns

ns

ns

ns

ns

Stored

Alive

2500 (90)

4.8 (1.05)

3.5 (0.20)

5.30 (0.52)

5.1 (0.8)

26.1 (2.42)

BD742 (65)

16.0 (1.98)

2.49 (0.37)

4.07 (0.17)

2.80 (1.19)

25.4 (4.57)

p < 0.0001

p < 0.0001

p < 0.02

ns

ns

ns

BD and HT

2074 (276)

4.6 (1.80)

3.10 (0.18)

9.66 (0.38)

9.65 (1.66)

21.2 (3.92)

ns

ns

ns

p < 0.0001

p < 0.05

ns

EXPERIMENTAL BRAIN DEATH

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