Secondary genetic events

Avet-Loiseau H, Gerson F, Margrangeas F et al. (2001) Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors. Blood, 98, 3082-3086.

Billadeau D, Liu P, Jelinek D et al. (1997) Activating mutations in the N- and K-ras oncogenes differentially affect the growth properties of the IL-6-dependent myeloma cell line ANBL6. Cancer Research, 57, 2268-2275.

Chesi M, Brents LA, Ely SA et al. (2001) Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood, 97, 729-736.

Corradini P, Ladetto M, Voena C et al. (1993) Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias. Blood, 81, 27082713.

Drach J, Ackermann J, Fritz E et al. (1998) Presence ofa p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy. Blood, 92, 802-809.

Fonseca R, Price-Troska T, Blood E et al. (2003) Implication of N-ras and K-ras mutation in clinical outcome and biology of multiple myeloma. Blood, 102, 113a.

Ge NL, Rudikoff S. (2000) Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo. Oncogene, 19, 4091-4095.

Guillerm G, Gyan E, Wolowiec D et al. (2001) p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance. Blood, 98, 244-246.

Hyun T, Yam A, Pece S et al. (2000) Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood, 96, 3560-3568.

Kulkarni MS, Daggett JL, Bender TP et al. (2002) Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis. Leukemia, 16, 127-134.

Liu P, Leong T, Quam L et al. (1996) Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood, 88, 2699-2706.

Neri A, Baldini L, Trecca D et al. (1993) p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy. Blood, 81, 128-135.

Shou Y, Martelli ML, Gabrea A et al. (2000) Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America, 97, 228-233.

Uchida T, Kinoshita T, Ohno T et al. (2001) Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia. Leukemia, 15, 157-165.

Urashima M, Teoh G, Ogata A et al. (1997) Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia. Clinical Cancer Research, 3, 2173-2179.

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