Polymerization of Hb S

This chemical reaction underlying sickling is a nucleus-mediated reaction. That is, a nucleus of about 10 hemoglobin tet-ramers has to form first, before the polymerization can start its characteristic exponential course to form sickle fibers. The formation of a nucleus is a hit-and-miss affair, and it takes time to form the right structure. Hence, the reaction has a delay time, after deoxygenation, that is shortened by an increase in intracellular hemoglobin concentration (above the normal 33 g/dl), by lowering the pH and by increasing the temperature. This explains why red cell dehydration and infections are serious in sickle cell anemia patients. The final products of polymerization are double-stranded fibers which lead to red cell deformity with protuberances (Figure 14.6).

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment