Molecular targets

rocal translocation of DNA between chromosomes 9 and 22 takes place. In the t(9;22), the distal ends of chromosomes 9 and 22 are exchanged in a so-called reciprocal translocation; that is, there is no overall net loss or gain of genetic material. The C-ABL proto-oncogene from chromosome 9 becomes joined to BCR (breakpoint cluster region) on chromosome 22, resulting in a chimeric fusion protein which has tyrosine kinase properties, and through some unknown mechanism leads to the typical CML phenotype (discussed in detail in Chapter 7).

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