Megaloblastic anemia

Table 12.1 Classification of the megaloblastic anemias.

FOLATE DEFICIENCY

Inherited

Acquired

Inborn errors of folate metabolism

Decreased intake

Congenital folate malabsorption

Old age, alcoholism

Dihydrofolate reductase deficiency

Hemodialysis

Methylene tetrahydrofolate reductase deficiency

Impaired absorption

Coeliac disease

Tropical sprue

Increased requirements

Pregnancy

Other increased cell turnover

Chronic hemolytic anemia

Drugs

Inhibitors of dihydrofolate reductase deficiency

Anticonvulsants

COBALAMIN DEFICIENCY

Inherited

Acquired

Inborn errors of cobalamin transport

Impaired absorption

Imerslund-Grasbeck disease

Gastric causes

Congenital deficiency of intrinsic factor

Pernicious anemia

Gastrectomy

Intestinal causes

Inborn errors of cobalamin metabolism

Blind loop syndrome

Methionine synthase deficiency (cblE and cblG)

Fish tapeworm

cblC and cblD disease

Pancreatic insufficiency

Decreased intake

Vegetarians

Other

Nitrous oxide exposure

OTHER

Hereditary orotic aciduria

Lesch-Nyhan syndrome

Thiamine-responsive megaloblastic anemia

Modified from Babior BM. (1995) The megaloblastic anemias edn. New York: McGraw-Hill, p. 471.

In: Beutler E, Lichtman MA, Coller BS, Kipps TJ. (eds). Williams Hematology, 5th

Supreme Sobriety

Supreme Sobriety

How to Maintain Your Resolution to Be Sober. Get All The Support And Guidance You Need To Be A Success At Sobriety. This Book Is One Of The Most Valuable Resources In The World When It Comes To Turning Your Love For Cooking Into A Money Maker.

Get My Free Ebook


Post a comment