Management

There is no specific treatment for these conditions. Patients with moderate anemia may require occasional blood transfusion when they experience exacerbations of the anemia due to an increased rate of hemolysis, or to decreased red cell production secondary to infection (the most extreme example being aplastic crisis from parvovirus infection). Patients with chronic severe anemia may require regular blood transfusion therapy with associated iron chelation. In some patients splenectomy has been beneficial. In severe cases bone marrow transplantation would be a rational form of treatment (for patients who have a suitable donor), provided there are no systemic manifestations other than hemolytic anemia, and provided it is carried out before there is organ damage (e.g. from iron overload).

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