Lymphoplasmacytoid lymphoma

strong surface expression of the CD30 (Ki-1) antigen, a cytokine receptor in the tumor necrosis factor receptor family. The majority of ALCL demonstrate T-cell surface markers and/or clonal rearrangements of the T-cell receptor locus. There are two main clinical forms: systemic and cutaneous. The cutaneous form is particularly indolent. While it is clinically aggressive, systemic ALCL is generally sensitive to chemotherapy. Approximately 30% of those diagnosed die of the disease.

Approximately 50% of the systemic ALCL carry the t(2;5), which confers a good prognosis. Long-term survival of t(2;5)-positive patients is 80% while that of t(2;5)-negative patients is 25%. The t(2;5)(p23;q35) results in a chimeric gene encoding a fusion of the nucleophosmin (NPM) and anaplastic lymphoma kinase (ALK) proteins. NPM is a multifunctional protein which has been implicated in ribosome assembly, control of centrosome duplication, and nuclear transport as a shuttle protein; it also possesses chaperonin and ribo-nuclease activities. ALK is a member of the insulin family of receptor tyrosine kinases. Its natural ligand is unknown. The NPM-ALK fusion contains the oligomerization domain of NPM and the tyrosine kinase domain of ALK. It results in a self-oligomerizing, constitutively active tyrosine kinase with transforming properties. NPM-ALK can activate numerous downstream effectors, including phospholipase C-y phopho-inositol 3'-kinase and RAS.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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