Chronic myeloid leukemia (CML) was the first hematological malignancy to be associated with a specific chromosome abnormality. This abnormality, known as the Philadelphia chromosome, results from a reciprocal translocation between chromosomes 9 and 22. This finding led to the identification of BCR-ABL as the causative molecular event of this disease and ultimately to the development of a therapy that targets this pathogenetic event. In this chapter, the clinical and molecular aspects of CML will be reviewed along with molecular methods of detection and monitoring of the disease. Treatment options are described, with emphasis on molecularly targeted therapy for this disease. Lastly, the signal transduction pathways affected by the BCR-ABL fusion protein will be discussed.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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