Genetic basis

G6PD is a homodimeric molecule, and its single subunit is encoded by an X-linked gene. As a result of the phenomenon of X-chromosome inactivation in somatic cells, female heterozygotes are genetic mosaics in whom approximately one-half of the red cells are normal and approximately one-half are G6PD-deficient. However, in some cases the ratio is imbal-anced. Therefore, clinical manifestations, such as favism, can occur in both hemizygous males and heterozygous females, but they tend to be milder in the latter, roughly in proportion to the fraction of red cells that are G6PD-deficient.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment