Cytogenetic and molecular abnormalities

Ahuja HG, Felix CA, Aplan PD. (1999) The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion. Blood, 94, 3258-3261.

Atoyebi W, Kusec R, Fidler C et al. (1997) Glutathione S-transferase gene deletions in myelodysplasia. Lancet, 349, 1450-1451.

Baxter EJ, Kulkarni S, Vizmanos JL et al. (2003) Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders. British Journal of Haematology, 120, 251-256.

Bench AJ, Nacheva EP, Hood TL et al. (2000) Chromosome 20 deletions in myeloid malignancies: reduction of the common deleted region, generation of a PAC/BAC contig and identification of candidate genes. UK Cancer Cytogenetics Group (UKCCG). Oncogene, 19, 3902-3913.

Boultwood J, Fidler C, Kusec R et al. (1997) Telomere length in myelodysplastic syndromes. American Journal of Hematology, 56, 266-271.

Boultwood J, Fidler C, Strickson AJ et al. (2002) Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome. Blood, 99, 4638-4641.

Gibbons RJ, Pellagatti A, Garrick D et al. (2003) Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS). Nature Genetics, 34, 446-449.

Golub TR, Barker GF, Lovett M et al. (1994) Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell, 77, 307-316.

Harada H, Harada Y, Tanaka H et al. (2003) Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood, 101, 673-680.

Hofmann WK, de Vos S, Komor M et al. (2002) Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood, 100, 3553-3560.

Horiike S, Yokota S, Nakao M et al. (1997) Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia, 11, 1442-1446.

Le Beau MM, Espinosa R 3rd, Davis EM et al. (1996) Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Blood, 88, 1930-1935.

Miyazato A, Ueno S, Ohmine K et al. (2001) Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction. Blood, 98, 422-427.

Padua RA, Guinn BA, Al-Sabah AI et al. (1998) RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up. Leukemia, 12, 887-892.

Pellagatti A, Esoof N, Watkins F et al. (2004) Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. British Journal of Haematology, 125, 576-583.

Ross TS, Bernard OA, Berger R et al. (1998) Fusion of huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGF-betaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood, 91, 4419-4426.

Rowley JD, Reshmi S, Sobulo O et al. (1997) All patients with the t(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders. Blood, 90, 535-541.

Rubin CM, Larson RA, Anastasi J et al. (1990) t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia. Blood, 76, 2594-2598.

Quesnel B, Guillerm G, Vereecque R et al. (1998) Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood, 91, 2985-2990.

Schoch C, Kohlmann A, Schnittger S et al. (2002) Acute myeloid leuke-mias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proceedings of the National Academy of Sciences of the United States of America, 99, 10008-10013.

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