Contents

List of Contributors, ix Foreword, xiii Preface, xv Abbreviations, xvii

1 Beginnings: the molecular pathology of hemoglobin, 1 David Weatherall

2 Molecular cytogenetics, 18

Debra M Lillington, Silvana Debernardi & Bryan D Young

3 Stem cells, 25

Eyal C Attar & David T Scadden

4 The genetics of acute myeloid leukemias, 41 D Gary Gilliland

5 Secondary myelodysplasia/acute myelogenous leukemia—assessment of risk, 47

D Gary Gilliland & John G Gribben

6 Detection of minimal residual disease in hematological malignancies, 53

Drew Provan & John G Gribben

7 Chronic myeloid leukemia, 72 Brian J Druker

8 Myelodysplastic syndromes, 82 Jaqueline Boultwood & James S Wainscoat

9 Myeloproliferative disorders, 90

Anthony J Bench, George S Vassiliou, Brian J P Huntly & Anthony R Green

10 Lymphoid neoplasms, 105 Anthony G Letai & John G Gribben

12 The molecular basis of anemia, 125 Lucio Luzzatto & Anastasios Karadimitris

13 The molecular basis of iron metabolism, 150 Nancy C Andrews

14 Hemoglobinopathies due to structural mutations, 159 Ronald L Nagel

15 Molecular coagulation and thrombophilia, 173 Björn Dahlbäck & Andreas Hillarp

16 The molecular basis of hemophilia, 184 Paul L F Giangrande

17 The molecular basis of von Willebrand disease, 199 Luciano Baronciani & Pier Mannuccio Mannucci

18 Platelet disorders, 210

Katherine A Downes & Keith R McCrae

19 The molecular basis of blood cell alloantigens, 225 Willem H Ouwehand & Cristina Navarrete

20 Functions of blood group antigens, 241 John R Pawloski & Marilyn J Telen

21 Autoimmune hematological disorders, 251 Drew Provan, James B Bussel & Adrian C Newland

22 Hematopoietic growth factors, 267 Graham Molineux

23 Molecular therapeutics in hematology, 280 A Keith Stewart & Jeffrey A Medin

24 Gene expression profiling in the study of lymphoid malignancies, 298

Ulf Klein & Riccardo Dalla-Favera

The molecular biology of multiple myeloma, 115 Appendices, 307

P Leif Bergsagel Index, 313

Color plate, facingp. 174

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