From the discovery of the Philadelphia chromosome to the molecularly targeted therapy of CML with imatinib, there is perhaps no other disease which has been so well characterized at the molecular level and in which the knowledge of the molecular biology has been exploited in diagnosis, disease monitoring and therapy. The current task for patients and their treating physicians is to make increasingly difficult decisions between treatment options. For the future, the goals will be to continue to improve and apply the knowledge of the molecular and immunological features of this disease to further improve treatment outcomes.
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