Animal models of CML

Several experimental approaches have demonstrated the ability of BCR-ABL to cause leukemia. In one set of experiments, transgenic mice that express BCR-ABL were shown to develop a rapidly fatal acute leukemia. Using a different approach, a BCR-ABL-expressing retrovirus was used to infect murine bone marrow. These BCR-ABL-expressing marrow cells were used to repopulate irradiated mice. The transplanted mice developed a variety of myeloproliferative disorders, including a CML-like syndrome. Although these approaches demonstrate the leukemogenic potential of BCR-ABL, it is possible that secondary changes are required for leukemia to develop. Recently, C. Huettner and colleagues placed BCR-

ABL under the control of a tetracydine-repressible promoter. Mice expressing this transgene develop a reversible leukemia dependent on the presence or absence of tetracycline, thus demonstrating the leukemic potential of BCR-ABL as a sole oncogenic abnormality.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment