It is accepted that increased angiogenesis is important in the pathophysiology of solid tumors. However, some recent studies show that angiogenesis and angiogenic factors may be important in MDS and AML. Both disorders are associated with an increase in the vascularity in the bone marrow as well as increased levels of various angiogenic factors, such as vascular endothelial growth factor, basic fibroblast growth factor, an-giogenin, platelet-derived growth factor, hepatocyte growth factor, epidermal growth factor, tumor necrosis factor-a, and transforming growth factor-p. The angiogenic factors may be secreted by the neoplastic cells and promote the growth proliferation of leukemic cells in an autocrine fashion. Blood levels of angiogenin and vascular endothelial factors are elevated in myelodysplastic syndromes and in acute myeloid leukemia. Again, as for apoptosis, the molecular basis of these observations is unknown.
with a diminution in the level of apoptosis. The molecular basis for these observations is unknown. Hopefully, studies of apoptosis alongside gene expression studies will help elucidate this phenomenon.
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.