Acute leukemias

LJ

der (15)

q

RARa PML

RARa t

RARa

Fusion gene

PML/RARa mRNA

PML/RARa fusion protein

Fig. 6.10 t(15;17)(q22;q21) translocation

A balanced translocation involving the RARa gene (at 17q21) and the PML gene (15q22), found in AML M3 (APML) in >90% of cases. The chimeric PML/RARa protein plays a role in the differentiation block characteristic of APML.

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