Monoallelic loss of 13q sequences is one of the most frequent abnormalities in MM (~50% of untreated cases by interphase FISH analyses) and is an independent predictor of a poor prognosis. Most often there is 13 monosomy, with selective loss of 13q sequences by interstitial deletion or translocation occurring much less frequently. The minimum region of deletion appears to be at 13q14, but biallelic deletion is rare. Notably, trisomy of chromosome 13 is also rare. The frequency of chromosome 13q loss increases with disease stage, from 20% in MGUS to nearly 70% in plasma cell leukemia or HMCL. In most patients, only a subset of MGUS tumor cells have the 13q abnormality, whereas for MM patients with an abnormality of 13q virtually all tumor cells have this abnormality. These results indicate that chromosome 13 losses begin in MGUS and increase in myeloma, but the nearly uniform presence of this abnormality in MGUS and myeloma tumors with t(4;14) or t(14;16) raises the possibility that this abnormality might
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