Cellular Models Of Depression Kindling model

Neurons which are repeatedly subjected to convulsions or electrical stimuli show a process of kindling, whereby the fit threshold is gradually lowered, and the cells eventually fire autonomously. Post has suggested that this phenomenon might underlie the tendency for some patients with affective disorder to suffer increasingly severe or refractory episodes of depression, or to require fewer provoking life events, with passing time. Strong support was provided by a study from Virginia (Kendler et al., 2000), which followed up over 2000 community-based female twin pairs over 9 years, measuring depression and lifeevent severity in this period. They found a clear tendency for each episode of depression to be followed by an increased subsequent risk of a further episode of depression. There was also a general tendency for each successive episode of depression to be less strongly related to preceding life stress. The mechanisms underlying this effect remain unclear, although suggestions are now being made that relate to the effects of gene expression, neural growth factors, and gene transcription changes; further work on these intriguing possibilities is needed.

BiPolar Explained

BiPolar Explained

Bipolar is a condition that wreaks havoc on those that it affects. If you suffer from Bipolar, chances are that your family suffers right with you. No matter if you are that family member trying to learn to cope or you are the person that has been diagnosed, there is hope out there.

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