The identification and optimization procedure described previously was used to estimate the parameters of the system kinetic expression and to determine the best utilization of a given volume of culture medium in order to maximize the productivity of a hybridoma cells culture. The total fermentation time was 10 days including both identification and the optimal control period. The final culture volume was fixed to be 2L.
In this study, the values of the rate of selection, crossover, and mutation in the GA were chosen as 0.08, 0.6, and 0.05 respectively.
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