The time for optimal control was eight days (the first two days of fermentation were used for parameters estimation). The optimal profiles obtained from the previous stage yielded a final MAb concentration of 193.1 mg/L and a final volume of 2L as shown in Figure 3.6 and Figure 3.7 respectively. The performance achieved by this on-line optimization is 2% less than the best result (196.27 mg/L) obtained in the case whereby all the parameters are assumed to be known in Chapter 2. This shows that the proposed real-valued GA approach can be a good alternative method for solving on-line identification and optimization problems.
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