Application of the optimal feed flow rates to the bioreactor

The time for optimal control was eight days (the first two days of fermentation were used for parameters estimation). The optimal profiles obtained from the previous stage yielded a final MAb concentration of 193.1 mg/L and a final volume of 2L as shown in Figure 3.6 and Figure 3.7 respectively. The performance achieved by this on-line optimization is 2% less than the best result (196.27 mg/L) obtained in the case whereby all the parameters are assumed to be known in Chapter 2. This shows that the proposed real-valued GA approach can be a good alternative method for solving on-line identification and optimization problems.

Fig. 3.6. The production of MAb.
Fig. 3.7. The history of culture volume.

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