Photos From The Cold Spring Harbor Laboratory Archives

Barbara McClintock and Robin HolBday, 1964 Symposium on Recombination at the DNA Level. McClintock proposed the existence of transposes to account for the results of her genetic studies with maize, carried out through tlie 1940s (Ciiapter 11); tile Nobel Prize in recognition of this work came mere than 30 years later, in 1983. Hoiliday proposed the fundamental model of homologous recombins tiort which bears his name (Chapter 10).

Reiji Okazaki

Reiji Okazaki, 1968 Symposium on Replication of DNA in Microorganisms. Okazaki had at this firne just shown how, during DNA replication, one of the new strands is synthesized in short fragments that are only later joined together. The existence of these "Okazakt fragments" explained how an enzyme that synthesizes DNA in only one direction can nevertheless mate two strands of opposite polarity simultaneously (Chapter 8).

Arthur Kornberg, 1978 Symposium on DNA: Replication and Recombination. Kornbcrg's extensive contributions to the study of DNA replica tton (Chapter 8) began with purifying the first enzyme that Could synthesize DNA, a DNA polymerase from £ coli His experiments showed that a DMA template was required for new DNA synthesis, confirming a prediction of the model for DNA replication proposed by Watson and Cndc For this work Kornberg shared in die 1959 Nobel Prize for Medicine.

Paul Modrich, 1993 Symposium on DNA and Chromosomes. A pioneer in the DNA repair fietd {Chapter 9), Modrich worked out much of the mechanistic basis of mismatch repair.

Matthew Meselson, 1968 Symposium on Replication of DNA in Microorganisms.

Meselson, with Frank Stahl, demonstrated that DNA is replicated by a semi-conservative medianen. This was once farrousty called "the most beautiful experiment in biology" (Chapter 2)

Franklin Stahl and Max Delbrück, 1956 Symposium on Exchange of Genetic Material: Mechanism and Consequences. Stahl was Meselson s parlnef in the experiment described above, and subsequently contributed much to our understanding of homologous recombination (Chapter iO). Delbrück was the influential cofounder of the socalled "Phage Croup"-a group of scientists that developed bacteriophage as the first model system of molecular biology (Chapter 21)-

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