Clr

HI 9 gene, 559- 60 Haeckel, Ernst, 6 hairpin DNA, 318 hairpin loops, 79 hairpin RNA. 361

Haldane, John Burden Sanderson, 15, 17 half-pint protein, 397 Hammarsten, Ola, 21 hammerhead ribozyme. 125. 126 hsploid cells. 132. 148. .580. 693-94 haploid-specific genes, 549 H2A.z, 165

heat denaturation. 109

heat shock <r factor, 499

Hedgehog, 700

helices, handedness, 103

helix-breaking residues, 74

helix-loop-helix motifs, 536, 536

helix-turn-helix motifs, 85, 354, 493, 494

hemoglobin, 29, 29. 37

Hemophilus influenzae, 663, 664-66

heredity. 8-9

Hershey, Alfred D., 21, 681, 692 heterochromatiri, 556-62 heterodimers, 535 heteroduplex DNA, 262

heterologous recombination, intermediates, 266 heterozygous genes, 7 hexapods. 630 hfl gene, 522

Hfr (high frequency recombinant) strains, 688

high-energy bonds, 58, 59, 60-61

Hin invertase, 297

Hin recombiniise, 305-7, 306

Hindlll restriction enzyme. 650

hinge helices, 89

histidine (His. II). 73 histone acetyl transferase (HAT)

complexes, 174, 540 histone chaperones. 173. 178-79 histone code hypothesis. 558 histone deacetylase, 557 histone deacetylase complexes, 174, 17-i liistone-DNA interactions, 153 hi stone-fold domains, 153. 154 histone Hi, 160, 161 histone methyl transferases, 557 histone methylases, 174, 274 histones chromosomes and, 129 gene silencing, 556-58 inheritance, 176, 176, 177,178 modification, 174 - 75, 558. 559 N-terminal tails. 159, 162, 169- 74.172. 17, nucleosome function and, 163-65 properties, 153, 153-54 structure, 154-56 HIV virus, 563, 567 hix recombination sites, 305, 306 hlf strain, 687 HLH proteins, basic, 53b HMG-r, 547 hnKNIJAl, 397 hnRNPt, 397, 398 HO genes, 546, 546, 580-83 Holliday junctions cleavage. 263 definition, 26(1 UNA cleavage, 276-77 formation, 300 generation, 262

recombination intermediates. 266 RuvAB complex recognition of, 276, 277 RuvC dimer binding. 278 Holliday model, 260-64, 261 holoenzymes, 537 Immeodomain proteins, 535 homeodomains, 535 liorneotic genes, 627-29 homologous recombination catalysis of, 269

chromosome segregation during meiosis, 27 circular DNA multimers. 307, 307-10 description. 259

double-strand break repair model, 264-66 in eukaryotes, 277-78 genetic consequences, 288-89 Holliday mode), 260-64 knockout technology» 707-9. 709 models of. 259-68 molecular level, 259-61 protein machines, 268—78 homologs, 131, 148 homozygous genes, 7 Horvitz, H. Robert. 698 house mouse, see mouse; Mus muscu/us Hax genes, 628, 629 Hoxb-2 genes, 707 llaxb genes, 628 Hoxd genes, 628 Hpal restriction enzyme, 651 HSF, 562

hsp70 control, 626

HSP70gene, 562-63 HU protein function, 306 humans evolution, 635 - 39 FGF genes. 615 FOXP2 gene. 638 gene con lit, 635-36 gene regulatory elements, 531> genome content. 137, 671 speoch, 637-39 synteny, 670 fitinc/ibocA gene, 592, 601, 602, 602-5, 603 Hunchback repressors. 608 Huxley, Julian, 15-16 Huxley. Thomas H.. 5 hybrid DNA, 262 hybrid dysgenesis. 703 -5, 704 hybridization, 108-9. 652-53. 657 hydrogen atoms, 42 hydrogen bonds

P sheet structure and, 77 base pairing and, 1(12 in biological molecules. 48 bond lengths, 47 characteristics, 47-48 directional properties, 49 DNA helix formation, 69-71, 70 protein structure and, 78-84 water molecules, 49 hydrolysis ATP, 61-67 definition, 58 in DNA synthesis. 183-84 peptide bonds, 60-61 types of damage by, 244 hydrolytic editing, 359 hydrophobic bonds, 51-52, 78 hydroxyl groups, 48 hyperchromicity, 110 hypoxanthine, 415

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