Results of Changing Injection Conditions

Figures 9 and 10 show the model calculated concentrations in the vitreous adjacent to the retina on the symmetry axis of the vitreous following 15 mL injections of fluorescein or fluorescein glucuronide, respectively, at the four different vitreous locations. Tables 2 and 3 contain the peak concentrations

Figure 8 Sites within vitreous where concentrations were monitored using the finite element model. In addition to studying the effects of injection position and volume on mean concentrations within the vitreous, concentrations were also monitored at several distinct points within the vitreous. The variation of drug concentrations within the vitreous will be revealed using this method of analysis.

Figure 8 Sites within vitreous where concentrations were monitored using the finite element model. In addition to studying the effects of injection position and volume on mean concentrations within the vitreous, concentrations were also monitored at several distinct points within the vitreous. The variation of drug concentrations within the vitreous will be revealed using this method of analysis.

and area-under-the-curve (AUC) values for all the vitreous sites and injection locations of fluorescein and fluorescein glucuronide.

In general, the data illustrate that injecting fluorescein or fluorescein glucuronide at different locations within the vitreous may produce significantly different local concentrations and concentration profiles. The peak concentrations that were calculated by the model depended on the location of the injection relative to the site where the concentration was monitored. The largest variations in the peak concentrations of fluorescein were observed at the vitreous site adjacent to the retina, where the retina-displaced injection produced a peak concentration over three orders of magnitude higher than that obtained from the hyaloid-displaced injection (Table 2). At the vitreous site adjacent to the hyaloid membrane, the peak concentration of fluorescein produced by the hyaloid-displaced injection was also over three orders of magnitude higher than the concentration produced by the retina-displaced injection. Peak concentrations of fluorescein at the vitr-

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