Results of Aphakia on Drug Distribution in the Vitreous

Figure 15 shows the model calculated concentration profile of fluorescein on half of a cross section of the vitreous 24 hours after a central intravitreal injection in the phakic and aphakic eye models. The concentration contours

Figure 15 Model calculated concentration profile of fluorescein on half of a cross-section of the vitreous 24 hours after a central intravitreal injection in the phakic eye model (A) and the aphakic eye model (B).

are parallel to the retina, as expected, since fluorescein is eliminated mainly across the retina. Table 6 lists the half-lives, mean concentrations, and peak concentrations of fluorescein within the vitreous as a function of injection position for both the phakic eye model or the aphakic eye model. Different

Table 6 Half-Life and Peak and Mean Vitreous Concentrations of Fluorescein Calculated Using the Aphakic and Phakic Eye Models Following Intravitreal Injections at Different Locations

Cpeak in vitreous

Table 6 Half-Life and Peak and Mean Vitreous Concentrations of Fluorescein Calculated Using the Aphakic and Phakic Eye Models Following Intravitreal Injections at Different Locations

Cmean in vitreous

Injection

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