Iontophoresis of pilocarpine (28) to induce sweating to measure sweat sodium and chloride concentration is the basis of the ''sweat test'' that is used to diagnose cystic fibrosis (29-31). High concentrations of both sodium and chloride ions in the sweat are considered as unequivocal evidence of the disease. Although essential criteria have been established for a positive test result in both children (30) and adults (31), pilocarpine iontophoresis should be used in conjunction with other clinical features to make a definitive diagnosis. This procedure is particularly useful in children younger than 1 year old because it is essentially painless and takes only 3-5 minutes to complete.
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