PVR can be induced by injecting dispase intravitreally to rabbits (Dutch belted, New Zealand white). Proliferative vitreoretinopathy developed in response to subretinal or intravitreal dispase, with or without retinal break. Severity of PVR was correlated with increasing doses of dispase. The dispase model of PVR is easy to perform, and it permits a clear view of the retina. This model showed a high success rate in development of PVR (52), and intravitreally administered prinomastat decreased development of PVR in this experimental model (53).
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