Which Questions Still Require Answering

C. albicans systemic infections appear to be most common in patients in ICU and those that have undergone surgery, yet it is still difficult to predict which patients are at greatest risk. Improvements in early diagnosis of fungal infections, without the need to culture the causative organism, will allow earliest initiation of antifun-gal therapy, and greatly increase the probability of a positive outcome. It is also important to consider the huge effect of biofilms on colonised catheters (another of the major contributing factors towards the likelihood of developing systemic can-didiasis). Further understanding of the biology of biofilm formation may lead to drug targets for prevention of their formation, or may suggest coatings for plastics to prevent biofilms. Biofilm formation by C. albicans can be affected by surface modification of plastics commonly used for medical devices, with 6% polyethylene oxide modification of polyetherurethane preventing biofilm formation (Chandra et al., 2005). The application of coated plastics for medical devices requires future research. However, the next big step in our understanding of systemic C. albicans infections will be investigation of how gene expression in the fungus changes during infection development in patients, which should now be possible by transcript profiling. It should also be possible to link changes in immune responses to the fungus with changes in fungal gene expression, or protein expression. It will also be possible to consider whether all isolates of C. albicans behave in a similar manner to cause infection and disease.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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