What Should Be the Goals of A fumigatus Research in the Next 510 Years

The aims of A. fumigatus research in the coming 'post-genomic' years, relating to its ability to cause disease, are to use new high-throughput methodologies to identify novel virulence factors and gain a better understanding of the host-pathogen interaction leading to the development of novel therapies for the treatment of IA and ABPA. As described in this review, many of the tools and methods to carry this out already exist, or have been developed for other fungi such as S. cerevisiae and C. albicans. The major operational goals for research laboratories specializing in A. fumigatus include the transcriptomic and proteomic analysis of A. fumigatus and the construction of knockout strains for most or all the ~9,900 genes in the A. fumigatus genome. The primary phenotype of the resulting mutant strains should be characterized and select mutants tested for virulence in several in vivo models of infection. An online database to house the accumulating data should be constructed. Finally, avirulent and hypervirulent mutants should be channeled into a host-pathogen and drug-discovery pipeline that could eventually yield novel treatments. Together, these approaches will allow our understanding of the pathogenesis of A. fumigatus to advance much more rapidly and yield substantial benefits in the near future.

Acknowledgements I thank the following members in my lab for their help in reading, editing, and preparing the figure for this manuscript: E. Levdansky, J. Romano, C. Sharon, and Y. Shadchkan. I thank D..S. Askew and J. C. Rhodes for critical reading of the section describing thermotolerance. I thank G. S. May, P. Dyer, I. Mouyna, and A. Beauvais for carefully reading this manuscript and adding appropriate comments and suggestions.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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