Unconventional Agents with Antifungal Activity

Many antineoplastic agents, natural plant products, and other drugs have been shown to exhibit wide spectrum antimycotic activity (Cardenas et al., 1999). Camptothecin, a topoisomerase I inhibitor, and some of its derivatives (Del Poeta et al., 1999), and eflornithine, an irreversible suicide inhibitor of ornithine decarboxylase (McCann and Pegg, 1992) exhibit significant activity against C. neoformans. Antifungal activity has been associated with immunosuppressants rapamycin, cyclosporin A, and FK506, the phosphatidylinositol 3-kinase inhibitor wortmannin, the angiogenesis inhibitors fumagillin and ovalicin, the hsp90 inhibitor geldanamycin and drugs that inhibit sphingolipid metabolism. The sodium channel blocker amiodarone, which treats arrhythmia was reported to have significant anti-S. cerevisiae activity (Courchesne, 2002; Courchesne & Oztruk, 2003). The drug was most potent against yeast mutants lacking key calcium transporter proteins (Cupta et al., 2003). The drug seems to mediate its cytotoxic activity by inducing gradual and sustained release of calcium from internal stores (Cupta et al., 2003). Although the antifungal activity was noticed only at toxic doses, combining a low dose of the drug with miconazole reduced the survival rate of S. cerevisiae to <10%. A low dose of the drug combined with fluoconazole resulted in close to 100% killing of C. albicans and C. neoformans in vitro.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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