Polyenes

Amphotericin B (AMB) and NY remain the most effective and widely used compounds in the treatment of presystemic and systemic fungal infections. Polyenes form complexes with ergosterol and disrupt the fungal plasma membrane resulting in increased membrane permeability and cell death. Auto-oxidation of ergosterol, results in the formation of free radicals and increased membrane permeability. Low affinity to cholesterol minimizes toxicity to mammalian cells due to polyene's (Abu-Elteen and Hamad, 2005; Groll and Kolve, 2004; Odds et al., 2003; Groll and Walsh, 2002). AMB lipid-based delivery systems enhance the therapeutic index by

Sordarin

Sordarin

GM193663

GM160575

222712 GM237354 H3C

222712 GM237354 H3C

GM160575

GM191519

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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