Pathophysiology

The main host defense mechanisms against zygomycetes are known and explain the risk factors for zygomycosis. Nevertheless, the pathophysiology of the disease remains largely unknown and there have been almost no studies performed during the last 10 years to uncover potential virulence factors or to evaluate the cellular and molecular interactions leading to infection. Angioinvasion with subsequent thrombosis and tissue necrosis is usually seen during zygomycosis. For this reason, one recent study focused on the interactions between zygomycetes and endothelial cells (Ibrahim et al., 2005b). It was shown that spores and germ tubes of R. oryzae adhere to endothelial cells, but only spores adhere to subendothelial matrix. Furthemore, damages of endothelial cells was demonstrated and required phagocytosis of the fungus. Interestingly, viability of the fungus was not required as dead R. oryzae was able to damage endothelial cells (Ibrahim et al., 2005b).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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