Dendritic Cells DCs and the Th1Th2 Response

DCs are key members of the innate immune system. They function to link the innate immune and adaptive immune responses. Immature DCs act as sentinels that take up antigens such as fragments of invading fungi. Thus activated, the DCs mature and migrate to regional lymph nodes. There they activate naive antigen-specific T cells, setting into motion the adaptive immune response, which can be a predominantly Th1 (cell-mediated) or Th2 (antibody mediated) (Buentke & Scheynius, 2003). It is generally accepted that Th1 responses confer protective immunity against infections with Aspergillus conidia, whereas a switch towards a Th2 response contributes to the development of IA (Bozza et al., 2002).

DCs recognize and react differently to A. fumigatus conidia and hyphae: phagocytosed conidia are bound to lectin-like receptors (murine MR, DEC-205, and human DC-SIGN receptors) on the surface of DCs and initiate an IL-12 Th1 mediated response (Bozza et al., 2002; Serrano-Gomez et al., 2005; Gafa et al., 2006). In contrast, hyphae bind CR3/FcyR II and III DC receptors, and initiate an IL-4/IL-10 mediated Th2 response (Bozza et al., 2002). The strong Th1 response initiated by conidial-activated DCs could be useful as a form of immunotherapy against IA (Bellochio et al., 2005).

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment