Dectin1 Receptor

Dectin-1 is a transmembrane C-type lectin receptor involved in the innate immune response to fungal pathogens. It is widely expressed and present on monocytes, macrophages, DCs, neutrophils, eosinophils, and a subset of T cells. Dectin-1 binds fungal cell wall P-glucans, activating src-family tyrosine kinase signaling to unknown downstream effectors. Dectin-1 activation mediates various cellular functions, including fungal binding, uptake, and oxidative killing and induction of cytokines and chemokine production (Brown, 2006). Recent evidence suggests that upon germination, A. fumigatus conidia shed their coating of hydrophobins to reveal underlying layers of P-glucan. The macrophage dectin-1 receptor binds to the exposed conidial P-glucan, enabling their subsequent phagocytocis and elimination (Hohl et al., 2005; Steele et al., 2005; Gersuk et al., 2006). This provides a mechanism by which pulmonary macrophages differentiate between nonactivating resting fungal spores, which are constantly inhaled, and activating potentially invasive (maturing) forms of the organism.

Recent studies suggest that there is cross talk between the dectin-1 and TLR pathways: Dectin-1 cooperates with TLR2 in mounting a strong phagocytic and inflammatory cytokine response to germinating A. fumigatus conidia (Luther et al., 2006; Gersuk et al., 2006).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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